Henry Hoffmann is a Professor and the Liew Family Chair of the Department of Computer Science at the University of Chicago. He received the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2019 (the highest honor the US government can bestow on early career researchers in science and engineering). He was granted early tenure in 2018. He is a member of the Samsung Security Hall of Fame and of the ASPLOS Hall of Fame. He has a Test of Time Honorable Mention from FSE 2021 for his work on Loop Perforation and approximate computing. He received the DOE Early Career Award in 2015.

At Chicago he leads the Self-aware computing group (or SEEC project) and conducts research on adaptive techniques for power, energy, accuracy, security, and performance management in computing systems. He co-founded Config Dynamics, LLC in 2019 to pursue commercial opportunities for self-aware computing. He has spent the last 22 years working on multicore architectures and system software in both academia and industry. He also founded the UChicago CS department's EDI committee in 2020.

He completed a PhD in Electrical Engineering and Computer Science at MIT where his research on self-aware computing was named one of ten "World Changing Ideas" by Scientific American in December 2011. He received his SM degree in Electrical Engineering and Computer Science from MIT in 2003. As a Masters student he worked on MIT's Raw processor, one of the first multicores.

Along with other members of the Raw team, he spent several years at Tilera Corporation, a startup which commercialized the Raw architecture and created one of the first manycores (Tilera was sold for $130M in 2014). His implementation of the BDTI Communications Benchmark (OFDM) on Tilera's 64-core TILE64 processor still has the highest certified performance of any programmable processor.

In 1999, he received his BS in Mathematical Sciences with highest honors and highest distinction from UNC Chapel Hill.