Introduction to Bioinformatics: CMSC54610-1, Spring quarter 2006.

Lecture 8: Genomics and Gene Recognition

• Prokaryotic Gene Structure
  • Figure 6.2:
  • Promoter elements
    • Table 6.2 lists common sequences for E. coli
  • Open reading frames
    • identified by start codon (for Met)
    • identified by runs without terminating codons
    • probability is (61/64)^N of having no terminators in N triplets
  • Conceptual translation: now dominates protein identification
  • Terminating sequences
    • loop structures and poly-U tail
    • RNA structure and Function
    • Vienna RNA Package

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