Explores the digital nature of biology at the molecular scale. Focuses on the role of the hydrophobic effect in protein/ligand associations. Utilizes data-mining as a tool both to understand basic biophysics and to explain protein-ligand associations. Shows how such analog interactions can lead to digital devices (e.g., switches). No biochemisty background will be assumed. All prerequisites will be provided in the class.
We will use nrpdb.tar.gz for some experiments with the PDB